17 - Improved Quality of Care and Quality of Life for IBD Patients using Healthpromise App: A Randomized, Control Trial

Measurement Information System domains, and other PROs, including disease activity assessments (the Simple Clinical Colitis Activity Index and the Short Crohn's Disease Activity Index).The population was separated into training and test sets.Potential questions were compared to the 4 SIBDQ domains and the composite SIBDQ using Wilcoxon Rank Sum and Pearson correlation analysis.Responsiveness of the measure to changes in disease activity was assessed using Wilcoxon Rank Sum testing.Results: Among 7,670 patients (63% CD, 37% UC), we identified candidate PRO questions based on correlations with each SIBDQ domain, with 5 PRO questions selected (Pearson correlation coefficient r ranging from 0.560-0.738,Table 1).The 5-question measure correlated well with the composite SIBDQ in the training (r=0.883,p<0.001) and test set (r=0.879, p<0.001).The 5-question measure also demonstrated significant responsiveness to changes in disease activity over time, in both CD and UC (Table 2).Conclusions: We created a novel measure of HRQOL that is composed of freely available PROs and demonstrates responsiveness to changes in disease activity among patients with both CD and UC.This potential new measure of HRQOL among patients with IBD decreases patient burden, and may offer substantial benefits as a new assessment tool in research settings and in clinical practice.