Mechanism Of Increased & It;In Vitro & It; Radio Sensitivity By Ceria Nanoparticle-Neogambogic Acid Combination

Nanomedicine, consisting of cytotoxic drugs and monodispersed nanoparticles with specific signals. has emerged as the novel radiosensitizer for breast cancer therapy. The radiosensitizer which can selectively increase cancer cell susceptibility to radiation can enhance the effectiveness of radiotherapy and minimize collateral damage. In this study, we evaluated the effect of ceria nanoparticles (CNPs) combined with the anticancer drug neogambogic acid (NGA-CPNs). Compared with CNPs, NGA-CNPs potentiated the effect of radiation, induced cell death, activated autophagy, and disordered mitochondrial membrane potential. These results suggest that NGA-CNPs can be used as an adjuvant treatment to increase cancer cell radio sensitivity.