Gabaergic Dysfunction In The Chronic Mild Stress Model: Modulation By Lurasidone Treatment

Andrea C. Rossetti,Maria Serena Paladini,Paola Brivio,Giulia Sbrini,Mariusz Papp,Francesca Calabrese,Raffaella Molteni,Marco Riva

BIOLOGICAL PSYCHIATRY（2018）

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摘要

Exposure of rats to chronic stress is able to produce functional alterations that are associated with different psychiatric disorders, which may be target of pharmacological intervention. The aim of the present study was to investigate the ability of a chronic treatment with lurasidone in normalizing the behavioral and molecular changes produced by chronic mild stress (CMS) in rats.

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关键词

Chronic Stress, Parvalbumin Interneurons, Oxidative Stress, Dorsal Hippocampus, Cognitive Impairment

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