Changes In Effective Hippocampal Network Coupling Mediate Learning And Memory Of Associations Between Temporally Discontiguous Stimuli

Episodic memory requires linking discontiguous events in time and depends on the hippocampus. This temporal association learning is often modeled using trace fear conditioning. Here we probe the ensemble activity in hippocampal CA1 during trace fear learning to differentiate between candidate activity mechanisms and directly resolve the underlying representation.