Neural Circuit Model Of Pharmacological Interventions To Large-Scale Cortical Dynamics Applied To Clinical Neuroimaging

Computational models of large-scale human brain circuits provide a useful framework to study relationships between synaptic-level alterations associated with neuropsychiatric disorders and neuropharmacology, and systems-level observations from non-invasive neuroimaging such as fMRI. Previously, we developed a modeling framework that incorporates heterogeneity of local recurrent strengths across the cortical hierarchy captured by myelin map topography. We found that microcircuit heterogeneity substantially increased the fit of the model to empirical resting-state functional connectivity (rs-FC) in healthy subjects.