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Plasma Interleukin 1 Beta Positively Correlates With Anxiety Scores In Youths With Bipolar Disorder

Kirti Saxena,Olaoluwa Okusaga,Ramandeep S. Kahlon,Ruchir P. Arvind,Christopher D. Verrico,Marguirite Patel,Ajay Shah,Shixia Huang,Danli Wu,Fuli Jia,Pooja A. Amin,Kathryn Durkin,Amy Vyas,Gabriel Rodrigo Fries,Gabriela Delevati Colpo,Cristian Patrick Zeni,Samuel Marazzo,Consuelo Walss-Bass,Laurel L. Williams,Iram Kazimi,Giovana Zunta-Soares,Jair C. Soares

BIOLOGICAL PSYCHIATRY（2018）

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Abstract
Bipolar Spectrum Disorders (BSD) and Anxiety Disorders are highly comorbid. Furthermore, school avoidance behavior can be a presenting symptom in youths with underlying anxiety. Immune dysfunction has been implicated in the pathophysiology of bipolar disorder but the role of immune markers such a proinflammatory cytokines in youths with bipolar disorder has not been adequately studied. We aimed to examine the association of the pro-inflammatory cytokine, IL-1β with anxiety symptoms and school avoidance behavior in youths with BSD.
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Key words
Anxiety, Mood Disorders, Bipolar Disorder, Metabolomics, Biomarkers
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