71. Convergence of Glutamatergic Mechanisms for the Generation of High Frequency EEG Noise

The negative symptoms remain among the most disabling and treatment refractory issues for people with schizophrenia Gap: Animal models of the negative symptoms of schizophrenia have been particularly challenging due to a dearth of manipulations with face or construct validity. Additionally, the lack of effective treatments for social and motivational deficits has impaired the ability to assess positive predictive validity from preclinical to clinical application. Despite these limitations, several lines of investigation suggest that alterations of N-Methyl D-Aspartate receptor-mediated glutamate transmission is related to negative symptoms.