Cell death after traumatic brain injury: Detrimental role of anoikis in healing
Clinica Chimica Acta(2018)
Abstract
Within the first few hours of a traumatic brain injury, the activity of extracellular matrix degradative enzymes increases. As a result, the blood brain barrier becomes disrupted as secondary white matter injury increases. Anoikis, a form of apoptosis, results from cells detaching from the extracellular matrix leading to cell death. This “homelessness” (anoikis) of cells hinders recovery progression, exacerbating brain injury while disrupting synaptic plasticity and other central nervous system functions. Here, we discuss the current knowledge of molecular pathways and proteins involved in both the activation and inhibition of anoikis.
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Key words
Anoikis,Traumatic brain injury,Apoptosis,Blood-brain barrier,Matrix metalloproteinase,Caspase
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