PD03-08 VITAMIN D, BONE TURNOVER MARKERS AND BONE MINERAL DENSITY IN RECURRENT CALCIUM STONE FORMERS

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology I1 Apr 2018PD03-08 VITAMIN D, BONE TURNOVER MARKERS AND BONE MINERAL DENSITY IN RECURRENT CALCIUM STONE FORMERS Urmila Dhakad, Bhupendra Pal Singh, Kawaljit Singh Kaura, Satya Narayan Sankhwar, and Siddharth Kumar Das Urmila DhakadUrmila Dhakad More articles by this author , Bhupendra Pal SinghBhupendra Pal Singh More articles by this author , Kawaljit Singh KauraKawaljit Singh Kaura More articles by this author , Satya Narayan SankhwarSatya Narayan Sankhwar More articles by this author , and Siddharth Kumar DasSiddharth Kumar Das More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.274AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of this study was to examine the status and interrelationship of vitamin D, bone mineral density, bone turnover markers in recurrent calcium stone formers. METHODS This prospective case control study was conducted between November 2015 and July 2017 at urology & rheumatology departments of a tertiary care teaching institution. A total of 99 adult subjects were recruited, including 55 patients of recurrent renal calcium calculi (Group A) and 44 healthy controls (Group B, without any history or evidence or intervention for urolithiasis). These subjects underwent metabolic evaluation including serum creatinine, calcium, phosphorous, sodium, potassium, uric acid, 25-OH-Vitamin D. Bone turnover markers studied were serum alkaline phosphatase and serum β-crosslaps levels. 24 hour urine tests included calcium, uric acid, phosphorous. Bone mineral density (BMD) was measured at multiple sites in body. Parameters between two groups were analysed and compared. The SPSS 16.0 statistics program was used for the analysis and p value ≤ 0.05 was considered statistically significant. RESULTS Mean age and sex ratio were similar between group A and group B (Table1). Mean serum 25-OH vitamin D levels (18.20±6.13 ng/ml vs. 21.79±6.20 ng/ml, p=0.042), serum alkaline phosphatase (235.15±58.22IU/L vs. 245.26±89.44 IU/L, p=0.046) and BMD at left forearm (0.810±0.118 vs. 0.866±0.093, p=0.030) were significantly lower whereas mean serum β-crosslaps levels (3700.86±1299. 01 pg/ml vs. 3583.53±1203.51 pg/ml, p=0.039), serum calcium levels (9.62±1.04 vs. 9.43±0.63 mg/dl; p=0.027) and 24 hours urine calcium (192. 95±93.87 mg vs. 122.93±72.82 mg, p=0.001) were significantly higher in recurrent stone formers as compared to controls. On multivariate analysis, 24 hour urine calcium (p=0.006), 24 hour urine phosphorous (p=0.019), 25-OH Vitamin D (p=0.029) and BMD right femur neck (p=0.032) were found to be risk factors associated with recurrent calcium stone formation. CONCLUSIONS Idiopathic recurrent calcium stone formation may results from complex interplay between low serum 25-OH vitamin D, higher normal serum calcium levels and higher urinary calcium excretion, with attendant low alkaline phosphatase and higher serum β-crosslaps levels. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e74 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Urmila Dhakad More articles by this author Bhupendra Pal Singh More articles by this author Kawaljit Singh Kaura More articles by this author Satya Narayan Sankhwar More articles by this author Siddharth Kumar Das More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...