CORRELATION OF MULTIPARAMETRIC MRI FINDINGS AND FINAL PROSTATECTOMY PATHOLOGY ACROSS THE PENNSYLVANIA UROLOGIC REGIONAL COLLABORATIVE (PURC)

You have accessJournal of UrologyImaging/Radiology: Uroradiology I1 Apr 2018MP14-19 CORRELATION OF MULTIPARAMETRIC MRI FINDINGS AND FINAL PROSTATECTOMY PATHOLOGY ACROSS THE PENNSYLVANIA UROLOGIC REGIONAL COLLABORATIVE (PURC) Serge Ginzburg, Edouard Trabulsi, Adam Reese, Bret Marlowe, Claudette Fonshell, John Danella, Thomas J. Guzzo, Thomas Lanchoney, Mark Mann, Jay D. Raman, Jeffrey J. Tomaszewski, Marc Smaldone, and Robert G. Uzzo Serge GinzburgSerge Ginzburg More articles by this author , Edouard TrabulsiEdouard Trabulsi More articles by this author , Adam ReeseAdam Reese More articles by this author , Bret MarloweBret Marlowe More articles by this author , Claudette FonshellClaudette Fonshell More articles by this author , John DanellaJohn Danella More articles by this author , Thomas J. GuzzoThomas J. Guzzo More articles by this author , Thomas LanchoneyThomas Lanchoney More articles by this author , Mark MannMark Mann More articles by this author , Jay D. RamanJay D. Raman More articles by this author , Jeffrey J. TomaszewskiJeffrey J. Tomaszewski More articles by this author , Marc SmaldoneMarc Smaldone More articles by this author , and Robert G. UzzoRobert G. Uzzo More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.512AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Fidelity of multiparametric MRI(mpMRI) interpretation may vary by institution. We characterize patterns of MRI utilization and quantify MRI-pathologic concordance across a regional collaborative. METHODS PURC is a prospective regional collaborative comprised of nine large academic and private urology practices in Southeastern PA and NJ, launched in 2015. Demographic and clinicopathologic data for patients with newly-diagnosed CaP were abstracted and mpMRI radiographic and pathologic concordance characterized using descriptive statistics. RESULTS Between May 2015 and September 2017, 5172 eligible patients were enrolled in PURC, 1724 (33%) had a mpMRI, 931(54%) of which contained detailed radiographic and clinicopathologic characteristics and comprised the cohort of interest (Table.)Most common magnet strength was 1.5Tesla(T) (55.5%), followed by 3T (26.7%) and unknown (17.7%.)Majority were imaged with endorectal coil (56.6%), 22.7% with surface body coil and 20.7% unknown. Radiographic evidence of extraprostatic extension(EPE) and seminal vesicle invasion(SVI) was observed in 9.1% and 4.1%, while pathologic EPE and SVI was present in 36.1% and 12.3%, respectively. Overall mpMRI sensitivity, specificity, positive and negative predictive values for EPE were 20.7%, 95.2%, 69.8% and 69.3%, and for SVI were 23.1%, 98.7%, 70.6% and 90.4%, respectively. Significant variation in mpMRI performace was observed between participating practices (Figure). Limitation of this analysis is inability to confirm laterality. CONCLUSIONS Despite poor sensitivity, radiographic evidence of EPE or SVI on mpMRI consistently predicted pathologic findings at prostatectomy with a high degree of specificity across a variety of practice settings in a large regional collaborative. Such data, shared across the collaborative, set an initial benchmark and inform individual practices if mpMRI quality gaps exist. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e188 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Serge Ginzburg More articles by this author Edouard Trabulsi More articles by this author Adam Reese More articles by this author Bret Marlowe More articles by this author Claudette Fonshell More articles by this author John Danella More articles by this author Thomas J. Guzzo More articles by this author Thomas Lanchoney More articles by this author Mark Mann More articles by this author Jay D. Raman More articles by this author Jeffrey J. Tomaszewski More articles by this author Marc Smaldone More articles by this author Robert G. Uzzo More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...