MP36-10 CHEST FOLLOW-UP SCHEDULE OF SURGICALLY RESECTED RENAL CELL CARCINOMA SHOULD BE DIFFERENTIATED ACCORDING TO HISTOLOGICAL SUBTYPE

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging II1 Apr 2018MP36-10 CHEST FOLLOW-UP SCHEDULE OF SURGICALLY RESECTED RENAL CELL CARCINOMA SHOULD BE DIFFERENTIATED ACCORDING TO HISTOLOGICAL SUBTYPE Michele Rizzo, Paolo Umari, Alessandro Volpe, Umberto Capitanio, Alessandro Antonelli, Maria Furlan, Carlotta Palumbo, Claudio Simeone, Francesco Montorsi, Alessandro Larcher, Roberto Bertini, Lorenzo Cancellieri, Francesco Porpiglia, Riccardo Bertolo, Enrica Verzotti, Nicola Pavan, Riccardo Campi, Andrea Cocci, Andrea Mari, Andrea Minervini, Francesco Alessandro Mistretta, Andrea Conti, Ottavio de Cobelli, Giovanni Liguori, and Carlo Trombetta Michele RizzoMichele Rizzo More articles by this author , Paolo UmariPaolo Umari More articles by this author , Alessandro VolpeAlessandro Volpe More articles by this author , Umberto CapitanioUmberto Capitanio More articles by this author , Alessandro AntonelliAlessandro Antonelli More articles by this author , Maria FurlanMaria Furlan More articles by this author , Carlotta PalumboCarlotta Palumbo More articles by this author , Claudio SimeoneClaudio Simeone More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Alessandro LarcherAlessandro Larcher More articles by this author , Roberto BertiniRoberto Bertini More articles by this author , Lorenzo CancellieriLorenzo Cancellieri More articles by this author , Francesco PorpigliaFrancesco Porpiglia More articles by this author , Riccardo BertoloRiccardo Bertolo More articles by this author , Enrica VerzottiEnrica Verzotti More articles by this author , Nicola PavanNicola Pavan More articles by this author , Riccardo CampiRiccardo Campi More articles by this author , Andrea CocciAndrea Cocci More articles by this author , Andrea MariAndrea Mari More articles by this author , Andrea MinerviniAndrea Minervini More articles by this author , Francesco Alessandro MistrettaFrancesco Alessandro Mistretta More articles by this author , Andrea ContiAndrea Conti More articles by this author , Ottavio de CobelliOttavio de Cobelli More articles by this author , Giovanni LiguoriGiovanni Liguori More articles by this author , and Carlo TrombettaCarlo Trombetta More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1144AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES European Association of Urology, National Comprehensive Cancer Network and American Urological Association provide follow-up guidelines for surgically treated Renal Cell Carcinoma (RCC). However these guidelines are not supported by good quality evidence. The potential exposure of the patients (pts) to the risks connected to unnecessary ionizing radiations is an important factor to consider. Aim of this study was to evaluate the oncological outcomes in a large cohort of pts to better tailor follow-up schedules of pts that underwent surgery for RCC. METHODS We enrolled 1932 pts surgically treated for sporadic pT1 pN0, M0 RCC from 7 Italian Accademic Centers with minimum follow-up of 6 months. The exclusion criteria were: high nuclear grade, presence of intratumoural necrosis, lymphovascular invasion, collecting system invasion, rare histological RCC subtype and positive surgical margin. Recurrences were classified in accordance to their location: abdomen, chest, multiple districts and other sites (including central nervous system, bone and skin). RESULTS Median age of the pts was 60 years (53-70). 1174 pts underwent partial nephrectomy and 758 radical nephrectomy. Histological subtype of the specimens were: 1491 Clear Cell RCC (ccRCC), 244 papillary RCC (pRCC) and 197 chromopobe RCC (chRCC). Median follow-up was 90 months (36-125). 145 (7,5%) pts developed a recurrence. Site and rate of recurrences are reported in table 1. Statistical analysis identifies a significant difference in the incidence of all site recurrences among all histological subtypes (P=0,0017); significant statistical difference was observed also in the incidence of primary chest recurrences for all histological subtypes (P=0,002). In the chRCC subgroup no chest recurrences were observed. 20 pts with ccRCC have a chest recurrence, 13 of them more than 5 years from surgery. CONCLUSIONS According to our data currently guidelines for RCC surveillance potentially expose a considerable number of pts to unnecessary chest examinations. Furthermore concluding follow-up after 5 years could lead to lose many primary chest recurrences in pts with ccRCC. In conclusion chest follow-up schedules should be differentiated and tailored on the basis of histological subtype. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e460-e461 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Michele Rizzo More articles by this author Paolo Umari More articles by this author Alessandro Volpe More articles by this author Umberto Capitanio More articles by this author Alessandro Antonelli More articles by this author Maria Furlan More articles by this author Carlotta Palumbo More articles by this author Claudio Simeone More articles by this author Francesco Montorsi More articles by this author Alessandro Larcher More articles by this author Roberto Bertini More articles by this author Lorenzo Cancellieri More articles by this author Francesco Porpiglia More articles by this author Riccardo Bertolo More articles by this author Enrica Verzotti More articles by this author Nicola Pavan More articles by this author Riccardo Campi More articles by this author Andrea Cocci More articles by this author Andrea Mari More articles by this author Andrea Minervini More articles by this author Francesco Alessandro Mistretta More articles by this author Andrea Conti More articles by this author Ottavio de Cobelli More articles by this author Giovanni Liguori More articles by this author Carlo Trombetta More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...