Mp35-17 comparison of cell cycle progression (ccp) score to two ihc markers (pten and ki-67) for predicting outcome in prostate cancer after radical prostatectomy.

You have accessJournal of UrologyProstate Cancer: Markers I1 Apr 2018MP35-17 COMPARISON OF CELL CYCLE PROGRESSION (CCP) SCORE TO TWO IHC MARKERS (PTEN AND KI-67) FOR PREDICTING OUTCOME IN PROSTATE CANCER AFTER RADICAL PROSTATECTOMY. Priscilla Leon, Geraldine Cancel-Tassin, Sarah Drouin, Marie Audouin, Justine Varinot, Eva Compêrat, xavier cathelineau, François Rozet, christophe vaessens, Steve Stone, William melbourn, Julia Reid, Zaina Sangale, Patrick Kormann, Morgan Rouprêt, Gaelle Fromont Hankard, and Olivier Cussenot Priscilla LeonPriscilla Leon More articles by this author , Geraldine Cancel-TassinGeraldine Cancel-Tassin More articles by this author , Sarah DrouinSarah Drouin More articles by this author , Marie AudouinMarie Audouin More articles by this author , Justine VarinotJustine Varinot More articles by this author , Eva CompêratEva Compêrat More articles by this author , xavier cathelineauxavier cathelineau More articles by this author , François RozetFrançois Rozet More articles by this author , christophe vaessenschristophe vaessens More articles by this author , Steve StoneSteve Stone More articles by this author , William melbournWilliam melbourn More articles by this author , Julia ReidJulia Reid More articles by this author , Zaina SangaleZaina Sangale More articles by this author , Patrick KormannPatrick Kormann More articles by this author , Morgan RouprêtMorgan Rouprêt More articles by this author , Gaelle Fromont HankardGaelle Fromont Hankard More articles by this author , and Olivier CussenotOlivier Cussenot More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1130AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previous studies of the cell cycle progression (CCP) score in surgical specimens of prostate cancer in patients treated by radical prostatectomy (RP) demonstrated a significant association with time to biochemical recurrence (BCR). In this study, we evaluated and compared the ability of the CCP score and the expression of PTEN or Ki-67 to predict BCR ina cohort of patients treated by RP. Finally, we constructed the best predictive model for BCR incorporating the biomarkers and relevant clinical variables. METHODS The study population consisted of 652 prostate cancer patients enrolled in a retrospective cohort and who had RP surgery in French urological centers from 2000 to 2007. RESULTS Among the 652 patients with CCP scores and complete clinical data, BCR events occurred in 41%, and time from surgery to last follow up among patients free of BCR was 72 months (Table 1). In univariate Cox analysis, the continuous CCP score and positive Ki-67 predicted recurrence with an HR of 1.44 (95% CI: 1.17-1.75; p=5.3 x 10-4) and 1.89 (95% CI: 1.38-2.57; p=1.6 x 10-4), respectively (Table 2). In contrast, PTEN expression wasn't associated with the risk of BCR. Of the 3 biomarkers, only the CCP score remained significantly associated in multivariable Cox model (p = 0.026) (Table 3). The best model incorporated CAPRA-S and CCP scores as predictors, with HR of 1.32 and 1.24, respectively. CONCLUSIONS CCP score was superior to the two IHC markers (PTEN and Ki-67) for predicting outcome in prostate cancer after radical prostatectomy. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e453-e454 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Priscilla Leon More articles by this author Geraldine Cancel-Tassin More articles by this author Sarah Drouin More articles by this author Marie Audouin More articles by this author Justine Varinot More articles by this author Eva Compêrat More articles by this author xavier cathelineau More articles by this author François Rozet More articles by this author christophe vaessens More articles by this author Steve Stone More articles by this author William melbourn More articles by this author Julia Reid More articles by this author Zaina Sangale More articles by this author Patrick Kormann More articles by this author Morgan Rouprêt More articles by this author Gaelle Fromont Hankard More articles by this author Olivier Cussenot More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...