Donor Mechanism of Death (MOD) and Interstitial Fibrin (INTFIB) as Predictors of Outcome After Heart Transplantation

Donor innate immune responses are triggered by donor brain death and activate cytokine responses including platelet activation and coagulation that may result in adverse cardiovascular outcomes (CVD). INTFIB is a marker of endothelial activation and plasma leakage in both innate and alloimmune reactions. We hypothesized that specific donor MOD may result in early INTFIB and correlate with CVD.