Enzymatic synthesis of catechol-functionalized polyphenols with excellent selectivity and productivity

•Cross-linked tyrosinase aggregates are excellent catalysts for polyphenol synthesis.•Catechol-functionalized polyphenols are synthesized with high efficiency.•Biocatalytic synthesis of 3′-hydroxypterostilbene was first reported.•Incorporating DES into CLEAs can render the immobilized enzyme more active/stable.