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Survival strategies for mouse cerebellar Purkinje neurons lacking PMCA2

Christopher J. Roome,Ruth M. Empson

Neuroscience Letters（2018）

Cited 1|Views5
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Abstract
•PMCA2 is heavily expressed in the cerebellum and cerebellar Purkinje neurons.•Calcium extrusion by PMCA2 is critical for cerebellar function at both the cellular and synaptic circuit levels.•Cellular and circuit adaptations in PMCA2 knockout mice ensure Purkinje neuron survival.
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Key words
Cerebellum,PMCA2,Ataxia,Purkinje neuron
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