Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1

Riikka Oksala,Anu Moilanen,Reetta Riikonen,Petteri Rummakko, Arja Karjalainen,Mikko Passiniemi,Gerd Wohlfahrt,Päivi Taavitsainen,Chira Malmström,Meri Ramela, Hanna-Maija Metsänkylä,Riikka Huhtaniemi,Pekka Kallio,Mika Mustonen

The Journal of Steroid Biochemistry and Molecular Biology（2019）

引用 17|浏览22

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摘要

•ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme.•ODM-204 shows promising pharmacological properties both in vitro and in vivo in prostate cancer models.

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关键词

Castration-resistant prostate cancer,Dual inhibition,Xenograft models,Monkey PK/PD,Clinical study

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