EXOSOMES FROM INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES SALVAGE THE INJURED MYOCARDIUM BY MODULATION OF AUTOPHAGY

Michelle R. Santoso,Hiromi Sano,Yuko Tada,Raymond G. Sierra,Andrew B. Goldstone,Daniel von Bornstaedt,Cornelius Gati,Y. Woo,Phillip C. Yang

Journal of the American College of Cardiology（2018）

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摘要

Induced pluripotent stem cells and their differentiated cardiomyocytes (iCMs) have tremendous potential as patient-specific therapy for myocardial injury (MI). Our previous work showed that iCMs secrete paracrine factors, modulating apoptotic pathways to restore the murine peri-infarct region (PIR

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关键词

injured myocardium by modulation,autophagy,cell-derived

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