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SERS-based multiplex immunoassay of tumor markers using double SiO 2 @Ag immune probes and gold-film hemisphere array immune substrate

Zhe Wang,Hongqin Yang,Miaohao Wang,Lucia Petti,Tao Jiang,Zhenhong Jia,Shusen Xie,Jun Zhou

Colloids and Surfaces A: Physicochemical and Engineering Aspects（2018）

Cited 47|Views29
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Abstract
An ultrasensitive SERS-based multiplex immunoassay is proposed for detecting of multiple tumor markers. The sandwich immunoassay platform is constructed by two kinds of SiO2@Ag immune probes and the gold-film hemisphere array (Au-FHA) immune substrate, which has been used to simultaneously detect PSA and AFP in the clinical samples with a low limit of detections.
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Key words
Surface-enhanced Raman scattering (SERS),Immunoassay,Tumor markers
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