Synthesis and antiproliferative activity of flavonoid triazolyl glycosides

Sixteen flavonoid triazolyl glycosides 4-19 were synthesized in good yields via Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids 1-3 with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous methanol. The antiproliferative activity of the synthesized compounds against three human cancer cell lines (Hela, HCC1954 and SK-OV-3) in vitro was evaluated. Flavonoids 1, 2 and flavonoid triazolyl glycosides 7, 12, 17 exhibit potent antiproliferative activity against these cancer cell lines.