Progressive severe B cell and NK cell deficiency with T cell senescence in adult CD40L deficiency
Clinical Immunology(2018)
Abstract
•CD40 Ligand deficiency may result in severe B and NK loss over time.•T cell senescence is a novel finding in adult CD40 Ligand deficiency.•Long term follow-up of CD40 Ligand deficiency may reveal novel immunological findings.•CD40 Ligand deficient patients not undergoing HSCT should be closely monitored.
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Key words
CD40 ligand deficiency,B cells,Natural killer (NK) cells,CD4 T cells,T cell senescence
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