The Clinical Phenotypes of Anhedonia in Late Life Depression

Introduction: Anhedonia is a key depression symptom but there is significant heterogeneity in its severity across individuals with Major Depressive Disorder. Anhedonia likely reflects altered functioning of key brain circuits involved in the reward process but it is unclear whether increased anhedonia is associated with distinct clinical and cognitive symptoms. The purpose of this study is to examine demographic, clinical and cognitive characteristics associated with increased levels of anhedonia in older depressed adults.