Association of COL1A1 rs180012 SNP and Fibromyalgia Suggests the Implication of Collagen Structure in Musculoskeletal Pain

Fibromyalgia (FM) is a complex, chronic condition,which causes widespread musculoskeletal pain, fatigue and a variety of othersymptoms. Many polymorphisms related to neuroendocrine system function as theApoE isoforms, Val158Met polymorphism in COMT, as well as a 44 bp deletion located in 5-HTTLPR, have been studied.Other polymorphisms have been related to inflammatory response such as the 70 bp VNTR in IL-4 or to citokine levels. Furthermore,some studies focused on finding out new FM related SNPs, have been performed bygenome wide association scan (GWAS). The target of this work was to study apossible linkage of a collagen type I polymorphism (COL1A1 rs180012 SNP)affecting bone mineralization, with fibromyalgia. Results obtained show a clearassociation of ss homozygous genotype with FM patients no dependent onbone mineralization.