Ion channel dysfunction in cerebellar ataxia
Neuroscience Letters（2019）
Abstract
•Motor impairment in cerebellar ataxia results in part from neuronal dysfunction.•Mutations in specific ion-channels cause human cerebellar ataxia.•Ion channel dysfunction is present in models of polyglutamine Spinocerebellar Ataxia.•A therapeutic strategy targeting specific ion-channels exists for cerebellar ataxia.
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Key words
Spinocerebellar ataxia,Ion channel,Purkinje neuron,Electrophysiology,Channel activator,Potassium channel
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