IS THE ICIQ-SF QUESTIONNAIRE RELIABLE IN PREDICTING QOL OUTCOMES? RESULTS OF A PROSPECTIVE SINGLE-CENTER STUDY

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Male Incontinence: Therapy I1 Apr 2018PD26-04 IS THE ICIQ-SF QUESTIONNAIRE RELIABLE IN PREDICTING QOL OUTCOMES? RESULTS OF A PROSPECTIVE SINGLE-CENTER STUDY Manuela Tutolo, Marco Bianchi, Giulia Castagna, Alberto Briganti, Andrea Salonia, Steven Joniau, Ben Van Cleynenbreugel, Youri Bekhuis, Francesco Montorsi, Wouter Everaerts, and Frank Van der Aa Manuela TutoloManuela Tutolo More articles by this author , Marco BianchiMarco Bianchi More articles by this author , Giulia CastagnaGiulia Castagna More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Andrea SaloniaAndrea Salonia More articles by this author , Steven JoniauSteven Joniau More articles by this author , Ben Van CleynenbreugelBen Van Cleynenbreugel More articles by this author , Youri BekhuisYouri Bekhuis More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Wouter EveraertsWouter Everaerts More articles by this author , and Frank Van der AaFrank Van der Aa More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1343AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To assess the correlation between ICIQ-SF and EORTC QLQ-C30-QoL in a cohort of patients submitted to robot-assisted radical prostatectomy (RARP) at a single center. Likewise, we sought to test the association between ICIQ-SF and satisfactory QoL at different time points METHODS Complete data were available for 392 patients operated between September 2009 and August 2016. Data were prospectively collected in a compulsory regional database (Flemish Cancer Registry). Pre and postoperative ICIQ-SF and EORTC QLQ-C30-QoL questionnaires were available for each patient. Linear regression analyses were used to assess correlation between ICIQ-SF and QoL scores. QoL was defined as satisfactory (>=91), intermediate (81-90) and poor (<=80). Best cut-off methodology and univariable analysis were used to identify two different ICIQ-SF categories associated to satisfactory QoL outcomes. Multivariable analysis (MVA) was used to assess the correlation between ICIQ-SF and QoL, at different time points, after adjusting for clinical and pathological variables (i.e., age at surgery, pathological stage (pT), N stage (N), Gleason Score (GS), Erectile function (EF; defined by IIEF-EF domain score), and biochemical recurrence (BCR) RESULTS Mean follow-up was 13.5 months (median 13, range 12-43). Before surgery, 81% of patients reported an ICIQ-SF score of 0. At baseline, 176 patients had QoL scores of 100 (45%). At 12-mos assessment, 52.6% (n=206) of patients had QoL scores >= 80 and 52% (n=203) had an ICIQ-SF <=2. At linear regression analysis, 12-mos ICIQ-SF scores were significantly associated to 12-mos QoL (p<0.001, β -1,75). At 1-mo assessment, the best ICIQ-SF cut-off associated to 12-mos satisfactory QoL was 2, while the best cut-off value was 5 at 3- and 12-mos (all p <=0.003). At 1 month EF and ICIQ-SF <=2 were associated with satisfactory QoL at 12-mos evaluation (all p=0.001). At 3 months, only ICIQ-SF <=5 was associated to satisfactory QoL scores (p=0.001, OR 5.0, 95%CI: 1,93; 9,71). At 12 months, both ICIQ-SF and EF scores emerged to be predictors of satisfactory QoL (p=0.001, OR 8.2, 95%CI: 2,7; 14,2 and p=0.005, OR 1.07, 95%CI: 1,02; 95%CI: 1,133, respectively). CONCLUSIONS To the best of our knowledge, this is the first prospective, single center study comparing ICIQ-SF findings and the QoL outcomes addressed using the EORTC QLQ-C30, in a cohort of patients submitted to RARP. The ICIQ-SF showed to be highly correlated with satisfactory QoL at 12-mos assessment as from 1 month after surgery. Accordingly, ICIQ-SF assessment can help in patients counseling after surgery © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e553 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Manuela Tutolo More articles by this author Marco Bianchi More articles by this author Giulia Castagna More articles by this author Alberto Briganti More articles by this author Andrea Salonia More articles by this author Steven Joniau More articles by this author Ben Van Cleynenbreugel More articles by this author Youri Bekhuis More articles by this author Francesco Montorsi More articles by this author Wouter Everaerts More articles by this author Frank Van der Aa More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...