In silico Analysis for Functional Predicition of Salmonella typhi Gene in Human Infection through Threading Model

Salmonella typhi is the Gram negative bacteria that have the ability to infect humans via transferring an effector protein into host cells through type III secretion system. This effector protein starts interfering various host mechanisms which helps in bacterial survival. Antibiotics activate the immune system against infection but sometimes bacteria develop resistance by modulating its mechanism. The present study was carried out to explore an uncharacterized gene which may be involved in infection enhancement. YejF gene was selected from transcriptomic data analysis and its function prediction was done by in silico studies with the help of similarity in structure of YejF model to their homologs. This study revealed that YejF protein is a part of transporter family which is enrolled in probably transferring the effector protein into human cells.