Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms

Amaly Nokkari,Hadi Abou-El-Hassan,Yehia Mechref,Stefania Mondello,Mark S. Kindy,Ayad A. Jaffa,Firas Kobeissy

Progress in Neurobiology（2018）

引用 64|浏览12

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摘要

•The (kallikrein-kinin system) KKS mediates the pathophysiological features of neurological disorders regulating brain functions.•The inhibition or stimulation of the KKS receptors (B1R and B2R) can exhibit neuroprotective and/or neuropathological outcomes.•The altered KKS dynamics can be utilized as putative biomarkers in different neurological disorders.

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关键词

AD,AEDs,BBB,Bdk,BDNF,CPM,CNS,CSF,GCS,GPCRs,HO-1,HMWK,H/R,ICH,KA,KKS,B1R,B2R,KO,MCAO,mLFPI,NO,pCMVEC,PTSD,RBA-1,ROS,RAS,SE,STS,SAH,TLE,TK,TBI,WT

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