To Enhance the Physicochemical Properties of Metoprolol Succinate By Co-Crystal Technique

Metoprolol succinate is a selective beta receptor blocker having poor physico-chemical and micromeritic properties. Therefore the co-crystals of metoprolol have been attempted to improve its physic-chemical and micromeritic characteristics. The effect of different co-formers such as benzoic acid and salicylic acid on flow ability of metoprolol by co-crystal technique. The co-crystals were characterized by Infra-red spectroscopy(I.R).It was found that micromeritic properties such as angle of repose, and physicochemical properties such as melting point. of co-crystals were significantly improved than that of pure metoprolol succinate. Hence it could be concluded that co-crystals could be one of the effective approaches for improved performance of metoprolol succinate.