Effect of FGF/FGFR Signal in Fluid Shear Stress and Estrogen Regulating Bone Metabolism

Estrogen and fluid shear stress (FSS) play an important role in bone metabolism, displaying a synergistic effect. Fibroblast growth factors (FGFs) are also of great importance in bone development before and after birth. FGFs regulate downstream signaling pathway by activating FGF receptors (FGFRs) to control the expression of bone tissue cells. This paper conducts a brief discussion of the effect of FGF/FGFR as well as fluid shear stress and estrogen in bone metabolism regulation.