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HER2及FOXM1在结直肠癌中的临床意义及相互关系的研究进展

Ming LU,Kongwang HU

Tumori（2017）

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Abstract
结直肠癌的增殖、进展和转移是一个多因素参与的病理转变过程.人表皮生长因子受体2(human epidermal growth factor receptor 2,EGFR2, HER2)和叉头框M1(forkhead box M1,OXM1)均为原癌基因,这2种基因编码的蛋白在细胞的代谢、增殖、凋亡、迁移和侵袭等过程中起重要的作用,且FOXM1可能为HER2调控的下游位点.二者在结直肠癌中均存在高表达,并与临床病理参数和预后具有相关性,因此HER2与FOXM1可能在结直肠癌的诊断、治疗评估和预后中具有重要的参考价值,并有望成为结直肠癌靶向治疗新的作用靶点.本文旨在对HER2和FOXM1的作用机制、在结直肠中表达的临床意义及二者作用的相关性进行综述.
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Key words
Colorectal neoplasms,Receptor,epidermal growth factor,Forkhead box M1,Molecular targeted therapy
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