Central Venous-To-Arterial Partial Pressure Of Carbon Dioxide Difference Indicates The Prognosis Of Cancer Patients With Sepsis

This study aimed to investigate whether central venous-to-arterial partial pressure of carbon dioxide difference (Pcv-aCO2) indicates the prognosis of cancer patients with sepsis post-operation. Total 157 cases of cancer patients with post-operation infection were enrolled, 127 cases were diagnosed with sepsis and received early capacity recovery. These patients were divided into two groups: Group A (Pcv-aCO2 < 6 mmHg) and B (Pcv-aCO2 >= 6 mmHg). ROC curve analysis showed that three largest areas for ROC curve included Pcv-aCO2 (0.733), SOFA (0.768) and qSOFA (0.728). There was significant difference in survival between Group A and B (26.77 +/- 5.12 vs 19.60 +/- 12.13). Furthermore, we determined prognostic factors influencing the survival and identified Pcv-aCO2 as the significant factor of the survival by COX regression or logistic regression analysis. In conclusion, we added two indexes of qSOFA and SOFA for early detection and early diagnosis of sepsis with the introduction of the Sepsis-3.0 guidelines. The combination of Pcv-aCO2 with qSOFA and SOFA will help the diagnosis and prognosis of cancer patients with sepsis.