Bisphosphonates For The Treatment Of Patients With Cancer

Bisphosphonates inhibit osteoclasts activity and therefore reduce bone resorption. The main application of bisphosphonates in patients with cancer involves treatment of hypercalcemia, prevention of cancer treatment-induced bone loss, and decrease of the risk of skeletal-related events in patients with breast cancer or prostate cancer and bone metastases. For some time now there has been an increasing amount of data indicating that treatment with bisphosphonates improves survival of patients with early breast cancer. The activity is restricted to postmenopausal women or premenopausal patients whose treatment involves gonadotropin agonist.