Sleep disordered breathing is very prevalent in patients with lung cancer: Preliminary results of the SAIL study (Sleep Apnea In Lung cancer)

Introduction: A link between some tumors and Obstructive Sleep Apnea Syndrome (OSAS) has been reported. We studied the prevalence of OSAS in patients with a recent diagnosis of lung cancer. Methods: Prospective registered multicenter study (NCT02764866). The study was offered to 66 consecutive patients with lung cancer, including Home Sleep Testing (HST) and a sleep-related questionnaire. Anthropometric and epidemiologic data were recorded along with Apnea-hypopnea Index (AHI), Oxygen Desaturation Index (ODI), Snore Index (SI) and % of time with oxygen levels Results: Nine of the 66 patients refused to participate, 13 failed to comply with HST, and 2 studies were invalid. A total of 42 HST were valid for analysis. Mean BMI was 27.4 Kg/m2 (+5.5). A majority of patients snored (57%), 31% had witnessed apneas, and 20% had excessive daytime sleepiness. Mean sleep duration was 7 hours (+1.5) and mean Epworth score was 7.28 (+3.9). Median AHI was 20.09, and T90 10.5% (IQR: 2.8-39). Sleep disordered breathing was ruled out in 7 patients (16%), while 11 (26%) had mild, 13 (30.1%) had moderate, and 11 (26%) had severe OSAS. Conclusions: Preliminary results of the prospective SAIL study suggest that sleep disordered breathing may be very prevalent in patients with lung cancer.