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Heteroduplex Oligonucleotide As A Platform Technology To Modulate Blood-Brain Barrier Function In Vivo

Hiroya Kuwahara,J. Song, T. Shimoura,K. Yoshida-Tanaka,T. Mizuno, T. Mochizuki,K. Nishina,T. Nagata,H. Kusuhara,Takanori Yokota

JOURNAL OF THE NEUROLOGICAL SCIENCES（2017）

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Abstract
Background: The blood-brain barrier (BBB) is a pathologic site in many neurological disorders such as multiple sclerosis, brain ischemia, and neurodegenerative diseases. Modulation of BBB function by an oligonucleotide-based gene silencing would be beneficial for a variety of basic and clinical studies.
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vivo,blood-brain
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