Identification and Elimination of an Unexpected Catalyst Poison in Suzuki Coupling
Organic Process Research & Development(2018)
摘要
A Suzuki coupling reaction gave an uncharacteristically low conversion in a GMP campaign. Initial investigation revealed a palladium catalyst poison in the starting material. A temporary solution was developed along with contingency plans to enable successful material delivery. Further systematic studies led to the identification of elemental sulfur as the culprit. A “sulfur-free” synthesis of the starting material was developed for the next round of manufacturing.
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关键词
unexpected catalyst poison,suzuki coupling
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