Latin-America Pediatric Renal Transplant Registry: 2004-2012 Report.: Abstract# A359

Aim: Latin-America Pediatric Renal Transplant Registry began in 2003. The objective is to analyze and share the results of pediatric kidney transplantation performed in Latin America. Methods: Data of pediatric renal transplants performed on patients from 43 centers in 14 countries: Argentina, Brasil, Chile, Colombia, Costa Rica, Cuba, Ecuador, Guatemala, Honduras, México, Nicaragua, Paraguay, Perú y Venezuela between January 1st, 2004 and December 31st, 2012 was collected. Results: Data on 2944 renal transplants were obtained. Mean age was 11.4+3.6 years, 57% male. Main etiology were congenital uropathy/vesicoureteral reflux (28%), followed by glomerulopathy (23%), including 326(11%) FSGS, hereditary diseases(14.7%), vascular diseases(3.1%), unknown in 17%. Sixty percent of transplants were performed with deceased donors and initial immunosuppression consisted mainly of tacrolimus (77%), mycophenolic acid(71%), steroids(96%) and induction therapy with anti- IL-2R antibodies (72%)One year graft survival was 97% and 87% (p<0,05), respectively for living donors (LD) and deceased donors (DD). Graft loss incidence was 16%, most frequently caused by (in descending order) acute and chronic rejection, arterial or venous thrombosis, death with functioning kidney and recurrent renal disease. Patient survival at 1 and 3 years was 96% and 95%, respectively. Mortality rate was 4% mainly due to infection and cardiovascular disease. Conclusion: The results are comparable to that of other international centers. Efforts are being made to provide on-line data entry, in order to facilitate reporting, and to supply an exchange of information, among the participating centers, as with other centers in the world.