Using The Meta-Analysis To Evaluate The Value Of Mean Corpuscular Volume In Screening Thalassaemia In Guangdong Province In China

To comprehensively evaluate the clinical value of Mean Corpuscular Volume (MCV) in screening Thalassaemia in Guangdong Province in China by Meta-analysis. We searched the databases of PubMed, Wanfang, CBM and CNKI to retrieve relevant studies on screening for Thalassaemia from 1980 to 2015. Totally 306 literatures were screened out by computer, according to inclusive and exclusive criteria, 16 documents were involved for analysis. Firstly, we use the Quality Assessment of Diagnostic Accuracy Study (QUADAS) to evaluate the qualities of the including studies. Then, we use the Meta-Disc 1.4 software to analyze the characteristics fourfold table information. Heterogeneity was not found for threshold effect but for non-threshold effect, so Meta-analysis was performed using the random effects models. The results are as follows: pooled sensitivity is 94% (95% CI: 94%-95%), pooled specificity is 71% (95% CI: 70%-73%), DOR is 60.18 (95% CI: 25.63-141.33) and the Area Under Curve(AUC) of the SROC is 0.9620. Lastly, we adopt the methods of subgroup analysis to investigate the source of the heterogeneity. The results of screening object subgroup are shown that the DOR of the check-ups group is higher than the couples of child-bearing and the pregnant. The results of subgroup of the Thalassaemia types are as follows: the DOR of beta-Thalassaemia is higher than the DOR of alpha beta-Thalassaemia and the DOR of alpha-Thalassaemia. Therefore, we draw a conclusion that using the MCV in screening Thalassaemia in Guangdong Province has some clinical value. Especially in check-ups group, the MCV in screening beta-Thalassaemia have higher detection rate.