Synthesis and structure of (het)arylglutamic acids and pyroglutamic acid hydrazides

Hydrochlorides of (2 R *,3 R *)-3-(het)arylglutamic acid diesters were synthesized by esterification of the corresponding glutamic acids (Glu). Diesters reacted with hydrazine hydrate to give (4 R *,5 R *)-2-pyrrolidone-5-carboxylic acid hydrazides. Hydrochlorides of glutamic acids diesters were found to exhibit cardioprotective properties against acute and chronic stress myocardial damage.