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Temporal Relation Between Local Disease Progression In The Onset Site And Regional Spread Of Motor Symptoms In Amyotrophic Lateral Sclerosis

T. Kanouchi,T. Sekiguchi,S. Iida,Miho Akaza,Takanori Yokota

JOURNAL OF THE NEUROLOGICAL SCIENCES（2017）

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Abstract
Background: If ALS pathology progresses by a prion-like propagation among adjacent cells from a single seed, the faster the lower motoneurons in the onset site get involved (local progression time, LPT), the faster motor symotoms spread from the onset site to the other body regions (regional spread time, RST).
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Key words
lateral sclerosis,motor symptoms,local disease progression,amyotrophic,onset site
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