R2 Recovery Cycle For Neurophysiological Differential Diagnosis Of Corticobasal Degeneration From Progressive Supranuclear Palsy

Background: Progressive Supranuclear Palsy (PSP) and CorticoBasal Degeneration (CBD) are rapidly progressive neurodegenerative disorders, clinically featured by parkinsonism and additional debilitating symptoms. The differential diagnosis between PSP and CBD is difficult because of the overlap of clinical features. R2 Blink Reflex Recovery Cycle (BRRC) is a neurophysiological tool used to evaluate brainstem excitability. R2 BRRC is abnormal in several movement disorders as Parkinson’s disease and dystonia.