Pla-Hpc Fibrous Membranes For Temperature-Responsive Drug Release

In this study, Polylactic acid and Hydroxypropyl cellulose (PLA-HPC) fibers were fabricated by electrospinning. Methylene blue (MEB), as a model hydrophilic drug was embedded into PLA-HPC fibrous membranes. SEM results depicted that fibers are smooth, cylindrical, uniform and it confirmed the incorporation of MEB in PLA fibers alter the fibers morphology. Studies show the on-demand release of drug from PLA-HPC fibrous membranes under temperature stimuli which were absent in membranes manufactured out of PLA. This can be attributed to reversible volume phase transitions of HPC molecules in response to applied external temperature. This study may provide more efficient strategies for developing materials with on-demand drug release capability.