Abstract 17342: The Global Registry of Acute Coronary Events Risk Score Predicts Mortality in Patients With Acute Ischemic Stroke and Abnormal Serum Troponin

Introduction: Almost 20% of patients with acute ischemic stroke have abnormal serum troponin I (TnI) levels, which are associated with increased mortality. Previous studies provide limited evidence for further risk stratification in this population. Hypothesis: We hypothesized that acute coronary syndrome risk scores would predict mortality after ischemic stroke in patients with elevated TnI. Methods: Prospective database of 1718 acute ischemic stroke patients admitted to the University of Pittsburgh Medical Center from December 2008 to November 2010. We included 309 (18%) with TnI ≥0.1 ng/ml. Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores were calculated using chest X-ray to determine Killip class; TnI ≥0.5 ng/ml was used to define “positive biomarkers” based on prognostic value of this cut-off in prior studies of this population. We used Cox proportional-hazards models to determine the association of these risk scores with inpatient mortalit...