Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis

In plants, monoterpenes are a large family of volatiles that play essential roles in communicating with the surrounding environment, including pollinator attraction, pathogen defense, and plant–plant interactions (Sun et al., 2016). Dozens of monoterpene derivatives have been widely applied in the pharmaceutical, nutraceutical, flavor, and fragrance industries. Because of their high economic value, the biosynthesis of monoterpenes has been thoroughly studied (Degenhardt et al., 2009; Vranova et al., 2013).