GW28-e0140 Knockout of Small Ubiquitin-Like Modifier 1 Protects the Mice from Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction

Liuying Zheng,Guoxing Zuo,Huaxin Sheng,Kuan Wang,Wei Yang,Wulf Paschen,Xinping Du

Journal of the American College of Cardiology（2017）

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摘要

Small ubiquitin-like modifier (SUMO1-3) conjugation (SUMOylation), a post-translational modification, modulates activity of a large number of nuclear proteins, including transcriptional factors and chromatin-associated proteins, and plays a crucial role in heart development and pathogenesis of heart

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关键词

cardiac,pressure,ubiquitin-like,overload-induced

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