Promising anticancer drug thapsigargin: A perspective toward the total synthesis
SYNTHETIC COMMUNICATIONS(2018)
Abstract
The guaianolide ring containing sesquiterpene thapsigargin is found in the roots and fruits of Mediterranean plant Thapsia garganica L. It is known for its activity as a potent antagonist for Ca2+-ATPase (sarco-endoplasmic reticulum Ca2+-ATPase) inhibition. Recently, a prodrug mipsagargin is being investigated to target the blood vessel of the cancer cells for the treatment of tumors. The limited natural supply (low isolation and only localized growth (Mediterranean area)) from the natural sources strongly urges for the development of chemical synthetic strategies to access these natural products. This review pertain the various strategies used so far in the thapsigargin's synthesis, focusing on major contributions in the total synthesis till date. [GRAPHICS] .
MoreTranslated text
Key words
Anticancer,Baran's and Evans' synthetic strategy,Ley's and Christensen's approach,Mipsagargin,prodrug,SERCA,thapsigargin,total synthesis,tumors
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined