Sensitive on-chip detection of cancer antigen 125 using a DNA aptamer/carbon nanotube network platform

Vinayakumar Gedi,Chung Kil Song,Gae Baik Kim,Jin Oh Lee,Eunkyul Oh, Bum Seok Shin,Mingi Jung,Jinhee Shim,Haiwon Lee,Young-Pil Kim

Sensors and Actuators B: Chemical（2018）

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摘要

•The ssDNA aptamer for cancer antigen 125 (CA125) was selected through SELEX.•Specificity of aptamer to CA125 was validated using cell imaging and 3DN-CNT.•Biochip platform showed much improved sensitivity than that of 2D or ELISA.

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关键词

Aptamer,CA125,MUC16,Ovarian cancer,CNT,Immunoassay

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