Free PaperAnnular Plane Systolic Excursion Z-Score in Evaluation of Heart Systolic Function of Fetus with Heart Failure

To establish Z-score model for fetal tricuspid annular plane systolic excursion(FAM-TAPSE) and mitral annular plane systolic excursion(FAM-MAPSE) based on gestational age(GA), then to evaluate the ventricle systolic function of fetus with heart failure. 1024 normal fetuses and 24 fetuses with heart failure were involved FAM-TAPSE and FAM-MAPSE were measured by free angle M-mode echocardiography, Normal FAM-TAPSE and FAM-MAPSE Z-score models were constructed by using first standard regression analysis using GA as independent variable.The fetuses with heart failure were divided into left heart failure(LHF) group and right heart failure(RHF) group by Tei index.Subsequently, the two parameters between normal and fetuses with heart failure were compared. The models used to calculate Z-score for FAM-TAPSE and FAM-MAPSE were constructed,and GA had close correlation with them Compared with normal fetuses, the mean Z-scores of FAM-TAPSE and FAM-MAPSE were statistical different in fetuses with heart failure. The FAM-TAPSE and FAM-MAPSE Z-score declined in fetuses with heart failure and they can provide quantitative evidence in evaluation of heart systolic function, FAM-TAPSE and FAM-MAPSE Z-score would be markers for assessing heart systolic function in fetuses with heart failure.