Tricuspid Annular Plane Systolic Excursion Z-Score in Evaluation of Right Ventricle Systolic Function of Fetus with Ebstein Anomaly

To establish Z-score model for fetal tricuspid annular plane systolic excursion(FAM-TAPSE) based on gestational age(GA), then to evaluate the righet ventricle systolic function of fetus with Ebstein anomaly(EA). 1024 normal fetuses and 20 fetuses with EA were involved. FAM-TAPSE were measured by free angle M-mode echocardiography(FAM), Normal FAM-TAPSE models were constructed by using first standard regression analysis using GA as independent variable. FAM-TAPSE between normal and fetuses with EA were compared in ANOVA, and regression equation estimate was used to compare the relationship of FAM-TAPSE with right ventricle area(RVA). The models used to calculate Z-score for FAM-TAPSE were constructed,and GA had close correlation with them. Compared with normal fetuses, the mean Z-scores of FAM-TAPSE were statistical different in fetuses with EA, and FAM-TAPSE showed positive correlations with RVA. The FAM-TAPSE Z-score declined in fetuses with EA as the increasing areas of atrial right heart and they can provide quantitative evidence in evaluation of right heart systolic function, FAM-TAPSE Z-score would be markers for assessing right ventricle function in fetuses with EA,and provide help to the prognosis and the perinatal management.