A study to compare the efficacy of ormeloxifene with norethisterone and conventional oral contraceptive pills

Background: Dysfunctional uterine bleeding is one of the commonest conditions for which patients seek advice in gynaecological outpatient department. Objective of present study was comparative evaluation of ormeloxifene with norethisterone and conventional oral contraceptive pills in dysfunctional uterine bleeding.Methods: This randomized study was conducted on 300 cases of dysfunctional uterine bleeding and they were distributed into three groups. group I were given ormeloxifene 60 mg biweekly for first 12 weeks followed by 60 mg weekly for next 12 weeks. Group II were given norethisterone 5 mg BD from 5th to 25th day of cycle and group III were given oral contraceptive pills from 5th to 25th day of cycle.Results: Subjective improvement was outstanding in group I in comparison to other two groups. There was also statistically significant increase in Hb g/dl and statistically significant decrease in endometrial thickness.Conclusions: Ormeloxifene was found to be superior to both norethisterone and conventional OCPs.