Evaluation of PD-1 and PD-L1 levels in clear cell histologic subtypes of ovarian and uterine malignancies and correlation with stage and survival

Objectives: Clear cell carcinomas (CCCs) of the ovary and uterus are rare histologies that are associated with a poor prognosis. Gynecologic CCCs can arise in an inflammatory milieu, such as endometriosis, and non-gynecologic CCCs have shown response to therapeutic targeting of program cell death receptor (PD-1) and its ligand PD ligand-1 (PD-L1). Information regarding expression of tumor infiltrating lymphocytes (TILs), PD-1 or PD-L1 within gynecologic clear cell malignancies is limited.