P29-6 - Effects of Comprehensive Cardiac Rehabilitation on Left Ventricular Diastolic Function in Patients With Cardiac Disease

Background: Effects of cardiac rehabilitation (CR) on left ventricular (LV) diastolic function has not been fully studied. Diastolic dysfunction is recognized as an important predictor of heart failure. Therefore, it is necessary to clarify the effect of CR on diastolic function in patients with cardiac disease. Methods and Results: 105 patients with cardiac disease who had LV ejection fraction (LVEF) being 50% or more at discharge were retrospectively studied. Patients were divided into CR group and non-CR group. We analyzed clinical data and echocardiographic parameters at baseline and 6 months later. Furthermore, we divided each groups into higher E/e′ (15 < E/e′) group and lower E/e′ (8 < E/e′ < 15) group, and analyzed the effect on diastolic function. E/e′ was significantly improved in CR group (CR group: 14.5 ± 7.8 vs 11.4 ± 4.9, P < .05, non-CR group: 13.2 ± 6.8 vs 12.8 ± 6.4, NS), Furthermore, in higher E/e′ patients, E/e′ was significantly improved in CR group (CR group: 22.9 ± 8.2 vs 13.4 ± 7.3, P < .05, non-CR group: 22.7 ± 8.1 vs 19.7 ± 10.5, NS). In CR group, there was a significantly increase in peak VO2, however the change of E/e′ was not related with the change of peak VO2. Conclusion: The present study showed that CR improved both diastolic function and peak VO2 significantly, but the change of diastolic function was not related with the change of exercise capacity.